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邱晓挺

发布时间:2020/06/16 15:17 作者: 点击量:

邱晓挺个人简历

邮箱:qiuxiaoting@nbu.edu.cn

职称:副教授

学位:博士

学科:结构生物学、生物化学与分子生物物理学、海洋生物资源利用





教育与工作经历:

2003.09 - 2007.06 宁波大学 生命科学与生物工程学院 生物技术 理学学士

2007.09 - 2012.11 中国科学技术大学 生命科学学院 结构生物学 理学博士

2013.06 - 2018.06  宁波大学 海洋学院

2018.07 - 至今   宁波大学 食品与药学学院

2019.12-2020.6 西澳大利亚大学 分子科学学院 访问学者)


研究方向:

1. 生理活性次级代谢物的生物合成机制

2. 病原细菌药物靶点蛋白的结构与功能

3.  酶解海洋动物蛋白制备活性多肽

.

科研项目:

主持

国家自然科学基金委员会,青年科学基金项目,31400683,蓝藻铜绿菌素Choi基团生物合成途径解析,2015-012017-1220万元;

浙江省自然科学基金委员会,青年科学基金项目,LQ14C050001,蓝藻铜绿菌素Choi基团合成酶AerD的催化机制解析,2014-012016-125万元。


参与

国家科技部,国家重点研发计划重点专项项目,2018YFA0903004,藻毒素合成路径的研究及环肽活性物质的开发2019-072024-06807万元;

国家自然科学基金委员会,面上项目,31872540,坛紫菜环境适应机制中的脂质氧化代谢途径的研究,2019-012022-1268.4万元;

国家自然科学基金委员会,面上项目,31572638,雨生红球藻光合碳代谢和虾青素积累相关基因的克隆和表达研究,2016-012019-1269.4万元;

宁波市科技局,农业与社会发展攻关项目,2015C10026,富含脑黄金海洋微生物的筛选及开发应用研究,2015-072019-0360万元。



已发表SCI收录论文:

1. Ming T, Huan H, Su C, Huo C, Wu Y, Jiang Q, Qiu X, Lu C, Zhou J, Li Y, Su X*. Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta. FEBS Open Bio. 2021 11: 793-803.

2. Huan H, Jiang Q, Wu Y, Qiu X, Lu C, Su C, Zhou J, Li Y, Ming T*, Su X*. Structure determination of ferritin from Dendrorhynchus zhejiangensis. Biochem Biophys Res Commun. 2020 531:195-202.

3. Qiu X, Wei Y, Zhu W, Fu J, Duan X, Jin H, Zhu P, Zhou C*, Yan X*. Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin. J Struct Biol. 2020 209: 107415

4. Qiao L, Fang J, Zhu P*, Huang H, Dang C, Pang J, Gao W, Qiu X, Huang L, Li Y. A Novel chemoenzymatic approach to produce Cilengitide using the thioesterase domain from Microcystis aeruginosa Microcystin synthetase C. Protein J. 2019 38: 658-666.

5. Qiu X, Zhu W, Wang W, Jin H, Zhu P, Zhuang R, Yan X*. Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin. J Struct Biol. 2019 205: 44-52

6. Zhu W, Hong T, Wang W, Wei Y, Mao X, Qiu X*. Expression, purification and crystallization of the complex of RNA polymerase II carboxyl-terminal repeat domain kinase subunits CTK2-CTK3 from Saccharomyces cerevisiae. Protein Expr Purif. 2019 154: 112-117.

7. Si K, Ming T, Li Y, Qiu X, Chen L, Zhou J, Lu C*, Su X*, Li, Y, Cheong LZ. Heavy metal detoxification by recombinant ferritin from Apostichopus japonicus. RSC Advances. 2017 7: 41909-41918

8. Qiu X, Ge J, Gao Y, Teng M*, Niu L*. Structural analysis of Ca2+-binding pocket of synaptotagmin 5 C2A domain. Int J Biol Macromol. 2017 95: 946-953.

9. Zhuang R*, Lou Y, Qiu X, Zhao Y, Qian D, Yan X, He X, Shen Q, Qian L. Identification of a yeast strain able to oxidize and remove sulfide high efficiently. Appl Microbiol Biotechnol. 2017 101: 391-400.

10. Qiu X*, Xu C, Chen X. Crystallographic analysis of a cupin superfamily enzyme from Microcystis aeruginosa involved in aeruginosin biosynthesis. Acta Crystallogr Sect F Struct Biol Commun. 2015 71: 1511-1515.

11. Jin H, Go M, Yin P, Qiu X, Zhu P, Yan X*. Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study. Plos One. 2015 10: e0124673.

12. Xu C#, Ding R#, Chen X, Bao M, Qiu X*. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of AerF from Microcystis aeruginosa, a putative reductase  participating in aeruginosin biosynthesis. Acta Crystallogr Sect F Struct Biol Commun. 2015 71: 466-470.

13. Liu H, Gao Y, Zhang M, Qiu X, Cooper AJ, Niu L*, Teng M*. Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2. Acta Crystallogr D Biol Crystallogr. 2013 69: 1470-1481.

14. Qiu X, Tao Y, Zhu Y, Yuan Y, Zhang Y, Liu H, Gao Y, Teng M*, Niu L*. Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. J Struct Biol. 2012 180: 327-334.

15. Qiu X, Yuan Y, Gao Y*. Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 67: 1590-1594.

16. Qiu X, Huang K, Ma J, Gao Y*. Crystallization and preliminary X-ray diffraction crystallographic study of tRNA m1A58 methyltransferase from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 67: 1448-1450.

17. Qiu X, Huang K, Liu Y, Zhang X, Gao Y*. Cloning, expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of human synaptotagmin 5 C2A domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 67: 1375-1377.

18. You W, Qiu X, Zhang Y, Ma J, Gao Y, Zhang X, Niu L*, Teng M*. Crystallization and preliminary X-ray diffraction analysis of the putative aldose 1-epimerase YeaD from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 66: 951-953.




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