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刘力伟

发布时间:2020/06/16 15:10 作者: 点击量:

Curriculum Vitae: Liwei Liu

简历:刘力伟


工作单位: 宁波大学 食品与药学学院 海洋药学系

职称/学位:副教授/博士

学科方向:海洋药物学

邮箱Email:liuliwei@nbu.edu.cn

个人网站:https://www.researchgate.net/profile/Liwei_Liu7


教育

2010-2014  理学博士     微生物系        赫尔辛基大学      芬兰

2007-2010  硕士         微生物系        南开大学          中国

2003-2007  工学学士     生物工程系      合肥工业大学      中国


工作经历

2017-2019 博士后 生物学院                         灵顿维多利亚大学       新西兰

2015-2017 博士后 微生物资源前期开发国家重点实验室 中国科学院微生物研究所 中国


研究方向

1. 高通量筛选微生物来源生物活性化合物

2. 天然产物的药学作用机理和生态学作用机制的研究

3. 微生物天然产物的生物合成机制和重要功能蛋白的酶学反应机理

4. 微生物功能性分子的应用与推广


主持的科研项目

  • 2021-2024宁波市科技创新2025重大专项-全智能海洋药用基因与药源分子发掘技术平台-子课题(180万)

  • 2021-2023 宁波市公益基金-基于功能宏基因组学技术探索浙东海岸潮间带放线菌中新型抗生素先导化合物 (10万)

  • 2021-2022 天然药物及仿生药物国家重点实验室开放课题-代谢组学挖掘海洋‘未培养’微生物中的新型抗生素(3万)

  • 2020-2022 浙江省教育厅一般项目-进化分析和代谢组学挖掘海洋‘未培养’微生物中的新型抗生素(1万)

  • 2019-2024宁波大学科研启动项目-海洋未培养微生物中新型抗生素的挖掘和生物合成研究(50万)

  • 2017-2019中国国家科学基金-青年项目, 放线菌中五角多酚类化合物的基因组挖掘(31600016)(21万元)

  • 2017-2018中国博士后科学基金一等, mutingweicin生物合成中乙酰基转移的研究(2017M610123)(8万)

  • 2017-2018中国博士后国家交流计划引进项目资助(27万)


荣誉奖项

  • 2011 芬兰CIMO奖学金(国家级12万)

  • 2010 国家建设高水平大学公派研究生奖学金(国家级50万)


邀请报告

  • “首届粤港澳大湾区微生物资源调查暨未/难培养微生物分离与培养技术研讨会”. 2019年 12月12-14日。中国,广州。Bioprospecting of Marine Microbial Resources by New Cultivation Methods(邀请报告)

  • The Centre for Biodiscovery Symposium on Harnessing, killing, and being infected by microbes. Jun 16th, 2017, Alan MacDiarmid Centre, Wellington, New Zealand. The new natural products with potent bioactivities from Cyanobacteria and Streptococcus mutans. (Invited speaker)


发表论文

1. Discovery of New Secondary Metabolites from Marine Bacteria Hahella Based on an Omics Strategy. Shufen He, Peishan Li, Jingxuan Wang, Yanzhu Zhang, Hongmei Lu, Liufei Shi, Tao Huang,Weiyan Zhang, Lijian Ding, Shan He, Liwei Liu*. Marine Drugs 2022,20, 269.

2. A new strain of Neowestiellopsis (Hapalosiphonaceae): first observation of toxic soil cyanobacteria fromagricultural elds in Iran. Bahareh Nowruzi1*, Lenka Hutárová, Itzel Becerra Absalón, Liwei Liu. BMC Microbiology 2022,22,107.

3. Paraneptunicella aestuarii gen. nov., sp. nov., a member of the family Alteromonadaceae isolated from seawater in East China Sea. Yanzhu Zhang, Shufen He, Liufei Shi, Yang Liu, Deqiang Mao, Biyin Liu, Xiaoping He, Bahareh Nowruzi, Dawoon Jung, Weiyan Zhang, Lijian Ding, Shan He, Liwei Liu*. International Journal of Systematic and Evolutionary Microbiology 2021, 71(12).

4. Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway. Luke J. Stevenson, Joe Bracegirdle, Liwei Liu, Abigail V. Sharrock, David F. Ackerley, Robert A. Keyzers, Jeremy G. Owen*. RSC Chemical Biology. 2021. (DOI: 10.1039/D0CB00228C)

5. Accessing previously uncultured marine microbial resources by a combination of alternative cultivation methods.

Dawoon Jung, Biyin Liu, Xiaoping He, Jeffrey S. Owen, Liwei Liu, Ye Yuan, Weiyan Zhang, Shan He. Microbial Biotechnology 2021. (DOI: 10.1111/1751-7915.13782)

6. Application of in situ cultivation in marine microbial resource mining. Dawoon Jung, Liwei Liu, Shan He. Marine Life Science & Technology 2021,3:148–161.

7. An anaerobic bacterium host system forheterologous expression of natural productbiosynthetic gene clusters. Tingting Hao, Zhoujie Xie, Min Wang, Liwei Liu, Yuwei Zhang, Weicang Wang, Zhao Zhang, Xuejin Zhao, Pengwei Li, Zhengyan Guo, Chunbo Lou, Guodong Zhang, Geoff P. Horsman, Yihua Chen*. Nature communications 2019.10(3665).

8. Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp. and Their Antioxidant Effects. Chunzhi Gao, Zhengyan Guo, Xingzhong Lu, Haiyan Chen, Liwei Liu, Zhiguo Yu*, Yihua Chen*. Journal of Natural Product 2018. 81(9): 2069–2074.

9. The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450. Anu Humisto, Jouni Jokela, Liwei Liu, Matti Wahlsten, Hao Wang, Perttu Permi, Joao Paulo Machado, Agostinho Antunes, David P Fewer, Kaarina Sivonen*. Applied and Environmental Microbiolgy 2017. 84(3): e02321-17.

10. Secondary metabolites from Streptococcus mutans and their ecological roles in dental biofilm. Zhoujie Xie,Zhao Zhang, Liwei Liu, Xiaochen Liu, Yihua Chen. Chinese journal of biotechnology 2017 33(9),1547-1554.

11. Genome mining of natural products gene clusters in Streptococcus mutans from human caries. Liwei Liu, Tingting Hao, Zhoujie Xie, Yihua Chen*. Scientific Report 2016, 6, 37479.

12. Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena. Liwei Liu, Adnan Budnjo, Jouni Jokela, Bengt Erik Haug, Torgils Fossen, David P. Fewer, Matti Wahlsten, Perttu Permi, Kaarina Sivonen*. ACS Chemical Biology 2015, 10 (3):725–733.

13. Antifungal compounds from cyanobacteria.Tania K. Shishido, Anu Humisto, Jouni Jokela, Liwei Liu, Matti Wahlsten, Anisha Tamrakar, David P. Fewer, Perttu Permi, Ana P.D. Andreote, Marli F. Fiore, Kaarina Sivonen*. Marine Drugs 2015, 13(4): 2124-2140.

14. Pseudoaeruginosins, Nonribosomal Peptides in Nodularia spumigena. Liwei Liu, Adnan Budnjo, Jouni Jokela, Bengt Haug, David Fewer, Matti Wahlsten, Leo Rouhiainen, Perttu Permi, Torgils Fossen, Kaarina Sivonen, ACS Chemical Biology 2014,10(3).

15. 4-methylproline guided natural product discovery yielded novel cyclic nostoweipeptins and nostopeptolides. Liwei Liu, Jouni Jokela, Lars Herfindal, Matti Wahlsten, Jari Sinkkonen, Perttu Permi, David P Fewer, Stein Ove Døskel, Kaarina Sivonen*. ACS Chemical Biology 2014, 9(11): 2646-2655.

16. Nostosins, trypsin inhibitors isolated from the terrestrial cyanobacterium Nostoc sp. strain FSN. Liwei Liu, Jouni Jokela, Matti Wahlsten, Bahareh Nowruzi, Perttu Permi, Yuezhou Zhang, Henri Xhaard, David P. Fewer, Kaarina Sivonen*. Journal of Natural Product 2014, 77 (8): 1784–1790.

17. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Liwei Liu, Lars Herfindal, Jouni Jokela, Tania Keiko Shishido, Matti Wahlsten, Stein Ove Døskel, Kaarina Sivonen*. Marine Drugs 2014, 12 (4): 2036-2053.

18. Genome mining expands the catalytic potential of the cyanobactin natural product pathway to include N-prenylated and O-methylated linear peptides. Niina Leikoski, Liwei Liu, Jouni Jokela, Matti Wahlsten, Muriel Gugger, Cheryl Kerfeld, Alexandra Calteau, Perttu Permi, Kaarina Sivonen, David P. Fewer*. Journal of Chemistry and Biology 2013, 20: 1033-1043.

19. DsbM, a novel disulfide oxidoreductase affects aminoglycoside resistance in Pseudomonas aeruginosa by OxyR-regulated response. Xuehan Wang, Mingxuan Li, Liwei Liu, Rui Mou, Xiuming Zhang, Yanling Bai, Haijin Xu, Mingqiang Qiao*. Journal Microbiology. 2012, 50(6): 932-938.




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